Autoantibodies to the URNP particles: relationship to clinical diagnosis and nephritis-Reference-Cited by-同舟云学术

Autoantibodies to the URNP particles: relationship to clinical diagnosis and nephritis

Published:1991-02 Issue:2 Volume:83 Page:286-290
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

REICHLIN M¹,VAN VENROOIJ W J²

Affiliation:

1. Arthritis/Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK USA

2. Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands

Abstract

SUMMARY Precipitating autoantibodies to the URNP particles were used to select 80 patients, and were further characterized by immunoblotting and quantitative ELISA. These immunochemical results have been related to clinical diagnosis, the frequency of nephritis, and Raynaud's phenomenon. Autoantibodies to the 70-kD polypeptide of the Ul RNP particle were present in 16 out of 19 patients with mixed connective tissue disease (MCTD) and in 27 out of 61 patients with systemic lupus erythematosus (SLE). The ratio of anti-U1 RNP/Sm by ELISA and the frequency of antibody to 70-kD protein were directly related to the frequency of Raynaud's phenomenon and inversely related to the frequency of nehritis.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/83/2/286/42216877/j.1365-2249.1991.tb05629.x.pdf

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