Neutrophil chemotactic factor produced by Japanese encephalitis virus stimulated macrophages-Reference-Cited by-同舟云学术

Neutrophil chemotactic factor produced by Japanese encephalitis virus stimulated macrophages

Published:1991-11 Issue:2 Volume:86 Page:299-303
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

KHANNA N¹,AGNIHOTRI M¹,MATHUR A¹,CHATURVEDI U C¹

Affiliation:

1. Postgraduate Department of Microbiology, K. G. Medical College, Lucknow, India

Abstract

SUMMARY The mechanism of neutrophil leucocytosis in cases of Japanese encephalitis is not known. We here report that during Japanese encephalitis virus (JEV) infection in mice the splenic macrophages secrete a chemotactic factor that attracts the neutrophils. The peak activity of macrophage derived factor (MDF) was observed on day 7 following infection. The MDF acted in a dose-dependent manner. This chemoattractant was purified by low pressure liquid chromatography and gave a single band of 10 kD on silver stained polyacrylamide gel. The MDF was found to be heat resistant and sensitive to prolonged incubation with proteases.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/86/2/299/42213708/j.1365-2249.1991.tb05813.x.pdf

Reference28 articles.

1. Physicochemical characterization of chemotatic lymphokines produced by human T and B lymphocytes;Altman;J. Immunol,1975

2. Fatal outcome in Japanese encephalitis;Burke;Am. J. trop. Med. Hyg,1985

3. Variable effect on peripheral blood leucocytes during JE virus infection in man;Chaturvedi;Clin. exp. Immunol,1979

4. Cloning and characterization of cDNA for murine macrophage inflammatory protein (MIP) a novel monokine with inflammatory and chemokinetic properties;Davatelis;J. exp. Med,1988

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