Changes in serum immunoglobulin patterns in adults with common variable immunodeficiency-Reference-Cited by-同舟云学术

Changes in serum immunoglobulin patterns in adults with common variable immunodeficiency

Published:1991-04 Issue:1 Volume:84 Page:23-27
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

SELIGMANN M¹,AUCOUTURIER P²,DANON F¹,PREUD'HOMME J L²

Affiliation:

1. Laboratory of Immunochemistry and Immunopathology (INSERM U 108), St Louis Hospital, Paris, France

2. Laboratory of Immunology and Immunopathology (CNRS URA 1172), University Hospital, Poitiers, France

Abstract

SUMMARY Striking variations of serum immunoglobulin class and IgG subclass levels were observed in five patients with common variable immunodeficiency. They occurred mainly in untreated patients or, in those patients who received substitutive therapy, could not be merely due to replacement. They result in major changes in the immunoglobulin deficiency patterns, such as a shift from profound hypoimmunoglobulinaemia to IgA/IgG2/lgG4 deficiency or to isolated IgG2 deficiency. These findings have practical implications for the diagnosis and management of patients with primary humoral immunodeficiency.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/84/1/23/42216292/j.1365-2249.1991.tb08118.x.pdf

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