Affiliation:
1. Department of Pathology, University of Tasmania, Hobart, Tasmania, Australia
Abstract
SUMMARY
Prostaglandins have been implicated in the immune suppression associated with the development of some tumours. Application of the prostaglandin synthetase inhibitor indomethacin, to murinc skin prior to treatment with the chemical carcinogens benzo(a)pyrene (BP) or7, 12 dimethylbenz(a)anthracene (DMBA), restored contact sensitivity responses to2,4-dinitrofluorobenzene in BP- but not DM BA-treated mice. However, indomethacin failed to restore antibody responses in either group of mice. Prolonged treatment with BP or DMBA led to cutaneous tumour formation. Indomethacin was found to delay the onset and reduce the size of tumours in BP- but not DM BA-treated mice. It is proposed that prostaglandin-induced suppression of cellular cutaneous immunity may play a role in BP- but not DMBA-induced cutaneous carcinogenesis.
Publisher
Oxford University Press (OUP)
Subject
Immunology,Immunology and Allergy
Cited by
10 articles.
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