Affiliation:
1. The Developmental Center for Handicapped Persons, The Department of Biology and the Department of Psychology, Utah State University, Logan, UT, USA
Abstract
SUMMARY
Associations between C4 deficiency and autoimmune disorders have been found over the past several years. Since autism has several autoimmune features, the frequencies of null (no protein produced) alleles at the C4A and C4B loci were studied in 19 subjects with autism and their family members. The autistic subjects and their mothers had significantly increased phenotypic frequencies of the C4B null allele (58% in both the autistic subjects and mothers, compared with 27% in control subjects). The siblings of the autistic subjects also had an increased frequency of the C4B null allele, but this increase was not significant. The fathers had normal frequencies of this null allele. All family members had normal frequencies of the C4A null allele, all normal C4A and C4B alleles and all BF and C2 alleles.
Publisher
Oxford University Press (OUP)
Subject
Immunology,Immunology and Allergy
Cited by
68 articles.
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