Spontaneous development of autoimmune uveoretinitis in nude mice following reconstitution with embryonic rat thymus

Author:

ICHIKAWA T12,TAGUCH O2,TAKAHASHI T2,IKEDA H3,TAKEUCHI M12,TANAKA T2,USUI M-2,NISHIZUKA Y2

Affiliation:

1. Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Japan

2. Department of Ophthalmology, Tokyo Medical College, Tokyo, Japan

3. Department of Pathology, Aichi Medical University, Nagakute-cho, Aichi-ken, Japan

Abstract

SUMMARY This paper describes the spontaneous occurrence of an autoimmune uveoretinitis in nude (nu/nu) mice reconstituted when 4 weeks old by the grafting of rat embryonic thymus. The uveoretinitis was characterized histologically by progressive loss of the pholoreceptor layer, observed in 4.0, 17.6, 42.9% and 71.4 % of such mice at 3, 5, 7 and 12 months of age. respectively. Mice with uveoretinitis were shown to huve serum IgG antibody reactive by indirect immunofluorescence with retinal photo receptors, and with interphotoreceptor retinoid-binding protein (IRBP). but not retinal S-antigen. by immunoblotting and ELISA. A uveoretinitis could be adoptively transferred to syngeneic ungrafted nude mice by splenic CD4* T cells from diseased animals. This is the first experimental model of a (T cell mediated) autoimmune uveoretinitis which develops spontaneously and which is not dependent upon deliberate sensitization with retinal antigens and adjuvants.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Reference29 articles.

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