Pharmacokinetic properties of IB1001, an investigational recombinant factor IX, in patients with haemophilia B: repeat pharmacokinetic evaluation and sialylation analysis

Author:

Martinowitz U.1,Shapiro A.2,Quon D. V.3,Escobar M.4,Kempton C.5,Collins P. W.6,Chowdary P.7,Makris M.8,Mannucci P. M.9,Morfini M.10,Valentino L. A.11,Gomperts E.12,Lee M.12

Affiliation:

1. Institute of Thrombosis and Hemostasis and the National Hemophilia Center; Sheba Medical Center; Tel Hashomer; Israel

2. Indiana Hemophilia and Thrombosis Center; Indianapolis; IN; USA

3. The Hemophilia Treatment Center at Los Angeles Orthopaedic Hospital; Los Angeles; CA; USA

4. University of Texas Houston Health Sciences Center; Houston; TX; USA

5. Aflac Cancer Center and Blood Disorders Service; Emory University School of Medicine; Atlanta; GA; USA

6. Arthur Bloom Haemophilia Centre; University Hospital of Wales School of Medicine; Cardiff University; Cardiff; UK

7. KD Haemophilia Centre and Thrombosis Unit; Royal Free Hospital; London; UK

8. Sheffield Haemophilia and Thrombosis Centre; Royal Hallamshire Hospital; Sheffield; UK

9. Scientific Direction and A. Bianchi Bonomi Hemophilia and Thrombosis Center; IRCCS Cà Granda Foundation Maggiore Policlinico Hospital; Milan; Italy

10. Agency for Haemophilia; Azienda Ospedaliero-Universitaria Careggi; Florence; Italy

11. Rush Hemophilia and Thrombophilia Center; Rush University Medical Center; Chicago; IL; USA

12. Inspiration Biopharmaceuticals; Cambridge; MA; USA

Publisher

Wiley

Subject

Genetics (clinical),Hematology,General Medicine

Reference16 articles.

1. Pharmacovigilence studies in haemophilia;Ingerslev;Haemophilia,2007

2. National Hemophilia Foundation Hemophilia B (Factor IX) http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=181&contentid=46&rptname=bleeding

3. Haemophilias A and B;Bolton-Maggs;Lancet,2003

4. Hemophilia B: Christmas disease;Giangrande;Expert Opin in Pharmacother,2005

5. Haemophilia B: impact on patients and economic burden of disease;Gater;Thromb Haemost,2011

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