Miller’s seminal studies on the role of thymus in immunity

Author:

Ribatti D1,Crivellato E2,Vacca A3

Affiliation:

1. Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy

2. Department of Medical and Morphological Researches, Anatomy Section, University of Udine Medical School, Udine, Italy

3. Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy

Abstract

Summary The thymus is one of the two primary lymphoid organs. It is responsible for the provision of T lymphocytes to the entire body, and provides a unique microenvironment in which T cell precursors (thymocytes) undergo development, differentiation and clonal expansion. This review article summarizes the seminal work of the Australian scientist Francis Albert Pierre Miller concerning the description for the first time of the crucial role of the thymus for normal development of the immune system.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

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