Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes-Reference-Cited by-同舟云学术

Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes

Published:2010-09-15 Issue:2 Volume:162 Page:197-209
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

Mannering S I¹,Wong F S²,Durinovic-Belló I³,Brooks-Worrell B⁴,Tree T I⁵,Cilio C M⁶,Schloot N C⁷,Mallone R⁸,

Affiliation:

1. St Vincent's Institute, (and The University of Melbourne, Department of Medicine), St Vincent's Hospital, Fitzroy, Vic, Australia

2. Cardiff University, Centre for Endocrine and Diabetes Science, Cardiff

3. Benaroya Research Institute, Seattle, WA, USA

4. University of Washington, DVA Puget Sound Health Care System, Seattle, WA, USA

5. Department of Immunobiology, King's College School of Medicine, King's College London, Guy's Hospital, London, UK

6. Department of Clinical Sciences, Cellular Autoimmunity Unit, Lund University, Skåne University Hospital, Malmö, Sweden

7. German Diabetes Center, Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at the Heinrich-Heine-University Düsseldorf, Department for Metabolic Diseases at University Hospital, Düsseldorf

8. INSERM, U986, DeAR Lab Avenir, St Vincent de Paul Hospital, France

Abstract

Summary Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would greatly aid efforts to understand the pathogenesis of T1D and is also urgently required to guide the development of antigen-based therapies intended to prevent, or cure, T1D. Here we describe some of the assays used currently to detect autoreactive T cells in human blood and review critically their strengths and weaknesses. The challenges and future prospects for the T cell assays are discussed.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/162/2/197/41924724/j.1365-2249.2010.04237.x.pdf

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