Smoking and periodontal disease: discrimination of antibody responses to pathogenic and commensal oral bacteria

Author:

Hayman L1,Steffen M J1,Stevens J1,Badger E2,Tempro P2,Fuller B2,McGuire A2,Al-Sabbagh Mohanad2,Thomas M V2,Ebersole J L12

Affiliation:

1. Center for Oral Health Research

2. Department of Oral Health Practice, University of Kentucky, Lexington, KY, USA

Abstract

Summary Smoking is an independent risk factor for the initiation, extent and severity of periodontal disease. This study examined the ability of the host immune system to discriminate commensal oral bacteria from pathogens at mucosal surfaces, i.e. oral cavity. Serum immunoglobulin (Ig)G antibody reactive with three pathogenic and five commensal oral bacteria in 301 current smokers (age range 21–66 years) were examined by enzyme-linked immunosorbent assay. Clinical features of periodontal health were used as measures of periodontitis. Antibody to the pathogens and salivary cotinine levels were related positively to disease severity; however, the antibody levels were best described by the clinical disease unrelated to the amount of smoking. The data showed a greater immune response to pathogens than commensals that was related specifically to disease extent, and most noted in black males. Significant correlations in individual patient responses to the pathogens and commensals were lost with an increasing extent of periodontitis and serum antibody to the pathogens. Antibody to Porphyromonas gingivalis was particularly distinct with respect to the discriminatory nature of the immune responses in recognizing the pathogens. Antibody responses to selected pathogenic and commensal oral microorganisms differed among racial groups and genders. The antibody response to the pathogens was related to disease severity. The level of antibody to the pathogens, and in particular P. gingivalis, was correlated with disease severity in black and male subsets of patients. The amount of smoking did not appear to impact directly serum antibody levels to these oral bacteria.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Reference52 articles.

1. Oral multispecies biofilm development and the key role of cell–cell distance;Kolenbrander;Nat Rev Microbiol,2010

2. Mutualistic biofilm communities develop with Porphyromonas gingivalis and initial, early, and late colonizers of enamel;Periasamy;J Bacteriol,2009

3. Bacterial interactions and successions during plaque development;Kolenbrander;Periodontol 2000,2006

4. Oral biofilm architecture on natural teeth;Zijnge;PLoS ONE,2010

5. Supragingival and subgingival plaque: paradigm of biofilms;Palmer;Compend Contin Educ Dent,2010

Cited by 19 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3