Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition-Reference-Cited by-同舟云学术

Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition

Published:2010-02-02 Issue:3 Volume:160 Page:461-465
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

Choi R Y¹,Farquhar C¹²,Juno J³,Mbori-Ngacha D⁴,Lohman-Payne B¹,Vouriot F³,Wayne S³,Tuff J⁵,Bosire R⁶,John-Stewart G¹²⁷,Fowke K³⁸⁹

Affiliation:

1. Departments of Medicine

2. Epidemiology

3. Medical Microbiology

4. Paediatrics

5. Public Health Agency of Canada, Winnipeg, Canada, and Departments of

6. Kenya Medical Research Institute, Nairobi, Kenya

7. Global Health, University of Washington, Seattle, WA, USA, Departments of

8. Community Health Sciences, University of Manitoba

9. Medical Microbiology, University of Nairobi, Nairobi

Abstract

Summary The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women in Nairobi were followed with their infants for 1 year postpartum. Among 131 infants, those with the 868T allele were more likely than wild-type infants to acquire HIV-1 overall [hazard ratio (HR) = 1.92, 95% confidence interval (CI) 1.05, 3.50, P = 0.03; adjusted HR = 2.03, 95% CI 1.03, 3.98, P = 0.04], after adjusting for maternal viral load. This SNP (an allele frequency of ∼15% in our cohort) was associated with increased susceptibility to mother-to-child HIV-1 transmission, consistent with a previous study on this polymorphism among Nairobi sex workers.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/160/3/461/41924765/j.1365-2249.2010.04096.x.pdf

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