A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma-Reference-Cited by-同舟云学术

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A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma

Published:2011-07-15 Issue:1 Volume:42 Page:38-48
ISSN:0954-7894
Container-title:Clinical & Experimental Allergy
language:en
Short-container-title:Clin Exp Allergy

Author:

Barnes N.,Pavord I.,Chuchalin A.,Bell J.,Hunter M.,Lewis T.,Parker D.,Payton M.,Collins L. Pearce,Pettipher R.,Steiner J.,Perkins C. M.

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2222.2011.03813.x/fullpdf

Reference28 articles.

1. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2;Hirai;J Exp Med,2001

2. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor;Monneret;Blood,2001

3. A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+CD4+Th2 lymphocytes in response to mast cell supernatants;Gyles;Immunology,2006

4. Interaction between prostaglandin D2 and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells;Xue;Clin Exp Immunol,2009

5. Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells;Xue;J Immunol,2005

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