Anomalous expression of HLA class II molecules on keratinocytes and fibroblasts in hypertrophic scars consequent to thermal injury

Author:

CASTAGNOLI C1,STELLA M2,MAGLIACANI G2,ALASIA S TEICH2,RICHIARDI P1

Affiliation:

1. Department of Genetics, Biology and Medical Chemistry, Genetics Section, Turin University and Centra CNR for Immunogenetics and Histocompatibility, Turin, Italy

2. Department of Plastic Surgery and Burn Unit, Traumatological Centre, Turin, Italy

Abstract

SUMMARY Immunoperoxidase staining of skin sections obtained from 11 hypertrophic scars, six normotrophic scars and three samples of normal skin were performed using anti-HLA monoclonal antibodies (HLA-DR, -DQ, class I), anti-interleukin-2 receptor (IL-2R) and anti-CD1. Sections from all hypertrophic scars showed an anomalous expression of HLA-DR molecules on keratinocytes and fibroblasts. Moreover hypertrophic scars were characterized by dense infiltrates of IL-2R-positive cells and by the presence of abundant Langerhans (CD1+) cells in the epidermis and dermis. These results support the hypothesis that immunologic mechanisms play an important role in hypertrophic scarring and point to an involvement of cell-mediated immune phenomena.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

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