Affiliation:
1. Immunological Medicine Unit, Department of Medicine, Royal Postgraduate Medical School, London, England
Abstract
SUMMARY
Using a sensitive, quantitative, and non-invasive in vivo method, based on the specific binding of serum amyloid P component to amyloid fibrils, we have directly documented the spontaneous resolution of AA amyloid deposits in mice, and the prolonged existence thereafter of a primed state of enhanced susceptibility to further amyloid deposition. These results may have important implications for understanding and management of amyloidosis in humans.
Publisher
Oxford University Press (OUP)
Subject
Immunology,Immunology and Allergy
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