Participation of eosinophils in the toxic oil syndrome

Author:

TEN R M1,KEPHART G M1,POSADA M2,ABAITUA I2,SOLDEVILLA L2,KILBOURNE E M3,DUNNETTE S L1,GLEICH G J1

Affiliation:

1. Departments of Immunology and Medicine, Mayo Medical School and Mayo Clinic and Foundation, Rochester, MN, USA

2. Fondo de Investigaciones Sanitarias de la Seguridad Social, Madrid, Spain

3. Centers for Disease Control, Atlanta, GA, USA

Abstract

SUMMARY The participation of eosinophils in the Spanish toxic oil syndrome (TOS) was investigated. Eosinophil infiltration and degranulation in tissues from 52 patients with the TOS were examined by immunofluorescence staining for the eosinophil granule major basic protein (MBP). Serum MBP levels were determined in sera from 323 patients. Eosinophil infiltration and degranulation were found in several tissues, especially during the acute phase of the TOS, and serum MBP was significantly elevated during all phases of the disease, suggesting that eosinophils play a role in the pathogenesis of the TOS.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

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