Affiliation:
1. First Department of Internal Medicine. Faculty of Medicine, Kyushu University. Fukuoka, Japan
Abstract
SUMMARY
We measured in vitro C3 production by peripheral blood monocytes from patients with systemic lupus erythematosus (SLE), and found it to be significantly greater than that from normal controls. We also found that monocytes from SLE patients with active disease produced a markedly larger amount of C3 than those from SLE patients with inactive disease. Production of C3 by monocytes correlated with serum levels of anti-dsDNA antibodies and inversely correlated with serum C3 levels in SLE patients. Serial measurement of C3 in the culture supernatant from each SLE patient showed that C3 production by monocytes fell in parallel with a decrease of disease activity. The effect of corticosteroids was ruled out as there was no relation between the level of C3 production by monocytes and the dose of prednisolone. This seems to be the first study in which the C3 production was assayed at a cellular level in SLE patients, and this study suggests that the local C3 production is increased in SLE patients.
Publisher
Oxford University Press (OUP)
Subject
Immunology,Immunology and Allergy
Reference28 articles.
1. Studies of the in vivo behavior of human C′3 in normal subjects and patients;Alper;J. clin. Invest.,1967
2. Genetics of the complement system;Alper;Adv. hum. Genet.,1976
3. Molecular mechanism for feedback regulation of C4 biosynthesis in guinea pig peritoneal macrophage;Auerbach;J. exp. Med.,1984
4. Increased biosynthesis of complement components by cultured monocytes, synovial fluid macrophages and synovial membrane cells from patients with rheumatoid arthritis;Cellaer;Immunology,1980
5. Hypercatabolism of C3 and C4 in active and inactive systemic lupus erythematosus;Charlesworth;Ann. rheum. Dis.,1989
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