Erythrocytes of patients with paroxysmal nocturnal haemoglobinuria acquire resistance to complement attack by purified 20-kD homologous restriction factor-Reference-Cited by-同舟云学术

Erythrocytes of patients with paroxysmal nocturnal haemoglobinuria acquire resistance to complement attack by purified 20-kD homologous restriction factor

Published:1990-04 Issue:1 Volume:80 Page:109-113
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

OKADA N¹,HARADA R¹,OKADA H²

Affiliation:

1. Department of Microbiology, Fukuoka University School of Medicine, Nanakuma, Fukuoka, Japan

2. Department of Molecular Biology, Nagoya City University School of Medicine, Nagoya, Japan

Abstract

SUMMARY A 20-kD homologous restriction factor (HRF20) which is a membrane inhibitor of the terminal stage of human complement action can be detected by the monoclonal antibody IF5, and is deficient on abnormal erythrocytes as well as leucocytes from patients with paroxysmal nocturnal haemoglobinuria (PNH). The erythrocytes of PNH patients significantly improved their resistance to homologous complement after adsorption of purified HRF20.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/80/1/109/42217941/j.1365-2249.1990.tb06449.x.pdf

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