Mitogen activated protein kinases: a role in inflammatory bowel disease?-Reference-Cited by-同舟云学术

Mitogen activated protein kinases: a role in inflammatory bowel disease?

Published:2009-09-30 Issue:3 Volume:158 Page:272-280
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

Broom O J¹,Widjaya B¹,Troelsen J²,Olsen J²,Nielsen O H¹

Affiliation:

1. Department of Gastroenterology, Medical Section, Herlev Hospital

2. Institute of Cellular and Molecular Medicine, the Panum Institute, University of Copenhagen, Copenhagen, Denmark

Abstract

Summary Since their discovery more than 15 years ago, the mitogen activated protein kinases (MAPK) have been implicated in an ever-increasingly diverse array of pathways, including inflammatory signalling cascades. Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are characterized by the perpetual production of inflammatory mediators. Research into the transduction pathway behind this over-production has highlighted the potential mediating role for the MAPKs and their related signalling components. This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/158/3/272/41927022/j.1365-2249.2009.04033.x.pdf

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