IgM and IgG antibodies to hepatitis C virus in patients with mixed cryoglobulinaemia-Reference-Cited by-同舟云学术

IgM and IgG antibodies to hepatitis C virus in patients with mixed cryoglobulinaemia

Published:1993-11 Issue:2 Volume:94 Page:313-316
ISSN:0009-9104
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

L'ABBATE A¹,CUTRUPI S¹,ROGNETTA M¹,FABIANO C²,CRAXI A²

Affiliation:

1. Centre of Clinical Physiology, C.N.R., Reggio Calabria, Italy

2. Department of Internal Medicine, University of Palermo, Palermo, Italy

Abstract

SUMMARY To assess the relationship between hepatitis C virus (HCV) infection and essential mixed cryoglobulinaemia (EMC), sera from 23 patients with EMC were tested for IgG and IgM antibodies to HCV antigens and for HCV RNA. Quantitative HCV antibody studies were performed on scrum and purified cryoglobulin fractions. HCV antibodies of both IgG and IgM class were found in 22 (96%) patients. Ten of these were also HCV-RNA positives. Higher litres of anti-HCV IgM were present in the 11 patients with evidence of liver damage. Anti-HCV IgG antibodies were shown to be concentrated in the IgG fraction of cryoglobulins in all eight patients studied. These results strongly suggest a role for HCV in the pathogenesis of EMC.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/94/2/313/42211085/j.1365-2249.1993.tb03449.x.pdf

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