Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism

Author:

Shih D. Q.1,Nguyen M.1,Zheng L.1,Ibanez P.2,Mei L.1,Kwan L. Y.1,Bradford K.1,Ting C.3,Targan S. R.1,Vasiliauskas E. A.1

Affiliation:

1. Inflammatory Bowel & Immunobiology Research Institute; Cedars-Sinai Medical Center; Los Angeles; CA; USA

2. Pontificia Universidad Católica de Chile; Chile

3. Department of Pharmacy; SGV Medical Center; San Gabriel; CA; USA

Publisher

Wiley

Subject

Pharmacology (medical),Gastroenterology,Hepatology

Reference35 articles.

1. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+  T lymphocytes;Tiede;J Clin Invest,2003

2. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study;Present;N Engl J Med,1980

3. Azathioprine maintains long-term steroid-free remission through 3 years in patients with steroid-dependent ulcerative colitis;Chebli;Inflamm Bowel Dis,2010

4. Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease;Prefontaine;Cochrane Database Syst Rev,2009

5. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease;Prefontaine;Cochrane Database Syst Rev,2009

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