Impaired irinotecan biotransformation in hepatic microsomal fractions from patients with chronic liver disease
Author:
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2125.2010.03715.x/fullpdf
Reference34 articles.
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3. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11);Mathijssen;Clin Cancer Res,2001
4. Pharmacokinetics and pharmacodynamics of irinotecan during a phase II clinical trial in colorectal cancer. Pharmacology and Molecular Mechanisms Group of the European Organization for Research and Treatment of Cancer;Canal;J Clin Oncol,1996
5. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes;Iyer;J Clin Invest,1998
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