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The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation

  • Published:2010-11-11 Issue:6 Volume:70 Page:844-853
  • ISSN:0306-5251
  • Container-title:British Journal of Clinical Pharmacology
  • language:en
  • Short-container-title:

Author:

Helsby Nuala A.,Hui Chung-Yee,Goldthorpe Michael A.,Coller Janet K.,Soh May Ching,Gow Peter J.,De Zoysa Janak Z.,Tingle Malcolm D.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference33 articles.

1. Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat;Cohen;J Pharmacol Exp Ther,1970

2. Differential activation of cyclophosphamide and ifosfamide by cytochromes P450 2B and 3A in human liver microsomes;Chang;Cancer Res,1993

3. Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation;Xie;Pharmacogenomics J,2003

4. Activation of the anti-cancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics;Chen;Mol Pharmacol,2004

5. Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide;Huang;Biochem Pharmacol,2000

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