Dose titration of BAF312 attenuates the initial heart rate reducing effect in healthy subjects

Author:

Legangneux Eric1,Gardin Anne1,Johns Donald2

Affiliation:

1. Novartis Pharma AG; Basel Switzerland

2. Novartis Institutes for BioMedical Research; Cambridge MA USA

Funder

Novartis Pharma AG, Basel, Switzerland

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference21 articles.

1. The S1P1/S1P5 receptor modulator BAF312 reverses neurological deficits in ongoing EAE, reduces specific lymphocyte subsets in healthy volunteers and is a potential new multiple sclerosis treatment;Nuesslein-Hildesheim;Mult Scler,2009

2. Seabrook T Smith P Schweitzer A Wallström E Nuesslein-Hildesheim B Efficacy of the selective S1P 1/5 modulator, BAF312 in established EAE and redistribution of S1P 1 and S1P 5 in the inflamed human CNS tissue 2010

3. The immune modulator FTY720 targets sphingosine 1-phosphate receptors;Brinkmann;J Biol Chem,2002

4. Cell type-specific localization of human cardiac S1P receptors;Mazurais;J Histochem Cytochem,2002

5. Sphingosine-1-phosphate receptor signalling in the heart;Means;Cardiovasc Res,2009

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