An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib

Author:

Vij Ravi1,Siegel David S.2,Jagannath Sundar3,Jakubowiak Andrzej J.4,Stewart Alexander Keith5,McDonagh Kevin6,Bahlis Nizar7,Belch Andrew8,Kunkel Lori A.9,Wear Sandra10,Wong Alvin F.11,Orlowski Robert Z.12,Wang Michael12

Affiliation:

1. Washington University School of Medicine; St. Louis; MO; USA

2. John Theurer Cancer Center at Hackensack University; Hackensack; NJ; USA

3. Mount Sinai Medical Center; New York; NY; USA

4. University of Michigan Comprehensive Cancer Center; Ann Arbor; MI; USA

5. Mayo Clinic; Scottsdale; AZ; USA

6. University of Kentucky College of Medicine; Lexington; KY; USA

7. Tom Baker Cancer Centre; University of Calgary; Calgary; AB; Canada; AB; USA

8. University of Alberta Cross Cancer Institute; Edmonton; AB; Canada

9. Independent Consultant; San Francisco; CA; USA

10. Multiple Myeloma Research Consortium; Norwalk; CT; USA

11. Onyx Pharmaceuticals, Inc; South San Francisco; CA; USA

12. MD Anderson Cancer Center; Houston; TX; USA

Publisher

Wiley

Subject

Hematology

Reference37 articles.

1. Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies;Alsina;Blood (ASH Annual Meeting Abstracts),2007

2. Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events;Arastu-Kapur;Clinical Cancer Research,2011

3. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation;Blade;British Journal of Haematology,1998

4. Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients;Boyette-Davis;Journal of Pain,2011

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