Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects

Author:

Patat Alain,Parks Virginia,Raje Sangeeta,Plotka Anna,Chassard Didier,Coz F. Le

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference19 articles.

1. Lecozotan (SRA-333): a selective serotonin 1a receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties;Schechter;J Pharmacol Exp Ther,2005

2. 2  Pesci KM . SRA-333 (WAY-161333): validation of a LC/MS/MS assay for quantitation of SRA-333 and eltoprazine in human plasma (protocol 02_220). Protocol on file Wyeth Research RPT-45764 2002.

3. 3  Neelans EJ , French DC , Burghart PH . SRA-333: Partial validation of an improved LC/MS/MS method for the determination of SRA-333 and eltoprazine in human plasma (protocol 02_0761). Protocol on file Wyeth-Research RPT-49106, 2003.

4. 4  Burghart PH , McDevitt J , Lui Z . SRA-333: an ascending multiple dose study of the safety, pharmacokinetics, and pharmacodynamics of SRA-333 administered orally to healthy subjects (Protocol 3098A1-101-EU): SRA-333 Ex Vivo Protein Binding. Protocol on file Wyeth Research RPT-54545 2004.

5. 5  McDevitt J . SRA-333: ex vivo protein binding of SRA-333 in healthy subjects (Protocol 3098A1-100-EU). Protocol on file Wyeth Research LOG 2561-2801 2003.

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