Glomerular immune deposits in murine lupus models may contain histones-Reference-Cited by-同舟云学术

Glomerular immune deposits in murine lupus models may contain histones

Published:1992-12 Issue:3 Volume:90 Page:453-458
ISSN:0009-9104
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

SCHMIEDEKE T¹,STOECKL F¹,MULLER S²,SUGISAKI Y³,BATSFORD S¹,WOITAS R¹,VOGT A¹

Affiliation:

1. Institute of Medical Microbiology, Freiburg, Germany

2. Institut de Biologie Moleculaire et Cellulaire, CNRS, Strasbourg, France

3. Nippon Medical School, Tokyo, Japan

Abstract

SUMMARY Two types of lupus mice, NZB/NZW F1 female hybrids and mice with graft-rersus-host disease (GVHD). were studied. Histones H3 and H2A were detected by immunofluorcscenee in glomeruli of 22/22 proteinuric GVHD and 8/12 proteinuric NZB/W F1 female mice; in non-proteinuric animals. 3/5 GVHD and 2/27 NZB/W F1 female were positive. Using antibodies to histone peptides it was shown that mainly the N-terminal regions of histones H3 and H2A were exposed in glomerular deposits. Western blot analysis revealed antibodies lo histone subfractions in sera of 33/34 lupus mice that developed proteinuria. This study provides evidence that histones are involved in the pathogenesis of lupus nephritis.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/90/3/453/42212303/j.1365-2249.1992.tb05867.x.pdf

Reference30 articles.

1. Circulating DNA and lupus nephritis;Fournie;Kidney Int,1988

2. Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone;Rumore;J Clin Invest,1990

3. Antigen-specificity of antibodies bound lo glomeruli of mice with SLE-like syndromes;Termaat;J Am Soc Nephrol,1990

4. Histories have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis;Schmiedeke;J Exp Med,1989

5. DNA has no affinity for the GBM in vivo; binding is mediated by histone;Stoeckl;Kidney Int,1990

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