Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes-Reference-Cited by-同舟云学术

Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes

Published:1992-05 Issue:2 Volume:88 Page:356-359
ISSN:1365-2249
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

ITOH Y¹²,MARUYAMA N²,KITAMURA M²,SHIRASAWA T²,SHIGEMOTO K²,KOIKE T³

Affiliation:

1. Department of Biology, Faculty of Science, Okayama University, Okayama

2. Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo

3. Division of Internal Medicine, Chiba University, Chiba, Japan

Abstract

SUMMARY The effect of Lps locus and IL-6 on the production of SU (previously termed gp70), a mouse endogenous retroviral gene product, was studied. Back-cross studies using the progeny between (NZB × C3H/HeJ)F1 and C3H/HeJ mice indicate that the basal level of SU is not associated with the Lps locus on chromosome 4. Lipopolysaccharide (LPS) mitogen response-negative mice did not show the enhancement of serum SU production after LPS injection. Spleen cells from LPS-mitogen response-positive but not from negative mice showed increase of IL-6 synthesis in the presence of LPS. Since IL-6 may be involved in the production of serum SU, we tested the effect of IL-6 in a primary hepatocyte culture system. SU production was clearly enhanced in the presence of recombinant IL-6, indicating that IL-6 induced by LPS can enhance the expression of retroviral genome.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/88/2/356/42213198/j.1365-2249.1992.tb03087.x.pdf

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