Affiliation:
1. Second Department of Surgery, Division of Clinical Biochemistry, University of Vienna, Vienna, Austria
Abstract
SUMMARY
Human umbilical vein endothelial cells (HUVEC) were investigated for their ability to produce neopterin, a biochemical marker for an activated immune system. Interferon-gamma (IFN-γ), IL-1α, IL-2, IL-6, tumour necrosis factor-alpha, granulocyte/macrophage colony stimulating factor, phytohaemagglutinin and concanavalin A were used to stimulate HUVEC. While IFN-γ induced neopterin release from HUVEC in a time- and dose-dependent manner, all the other cytokines used had no effect on neopterin production. High neopterin levels are found in patients with rejection episodes or infections. Our results suggest that not only monocytes and macrophages, which are known to synthesize neopterin, but also endothelial cells are responsible for these high serum neopterin levels.
Publisher
Oxford University Press (OUP)
Subject
Immunology,Immunology and Allergy
Reference31 articles.
1. The pathogenesis of atherosclerosis;Ross;N Engl J Med,1986
2. The role of endothelial cells in inflammation;Pober;Transplantation,1990
3. The potential roles of vascular endothelium in immune reactions;Pober;Hum Immunol,1990
4. Interleukin-1 increases the binding of human B- and T-lymphocytes to endothelial cell monolayers;Cavender;J Immunol,1986
5. Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin-1, endotoxin and tumor-promoting phorbol diesters;Schleimer;J Immunol,1985
Cited by
29 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献