T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE)

Author:

LEVY E12,AMBRUS J2,KAHL L2,MOLINA H12,TUNG K3,HOLERS V M13

Affiliation:

1. Howard Hughes Medical Institute Laboratories, Washington University School of Medicine, St Louis, MO, USA

2. Department of Medicine, Washington University School of Medicine, St Louis, MO, USA

3. Department of Pathology, Divisions of Rheumatology and Laboratory Medicine, Washington University School of Medicine, St Louis, MO, USA

Abstract

SUMMARY Complement receptor 2 (CR2, CD21), the receptor for both the C3d,g portion of human complement component C3 and the Epstein-Barr virus, has been recently described on peripheral T cells. By using dual stain flow cytometric analysis, we have also observed that a peripheral T lymphocyte subpopulation of normal healthy donors bears CR2 in a range varying from 1·1 to 23/2% (mean 12·6%) of total CD3+ cells. T lymphocytes from nine patients with inactive SLE expressed CR2 in a similar range. Three patients with active SLE were also studied. One of them, having neuropathy and glomerulonephritis, displayed an expansion of the CR2+ T cell subpopulation which reached as much as 89% of total CD3+ cells. To examine potential functional roles of T cell CR2, cells from a Jurkat-derived CR2 expressing T cell line were found to bind in vitro to human CR2−, complement-coated K562 cell targets in a CR2- and complement-dependent fashion. Based on these studies, we hypothesize that CR2 might act to increase adherence of T cells to nucleated target cells bearing C3d,g, a function which may be relevant to cytotoxicity or other T cell activities requiring cell-cell interaction.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

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