Changes in circuIating B cells and immunoglobulin cIasses and subcIasses in a healthy aged popuIation-Reference-Cited by-同舟云学术

Changes in circuIating B cells and immunoglobulin cIasses and subcIasses in a healthy aged popuIation

Published:1992-11 Issue:2 Volume:90 Page:351-354
ISSN:0009-9104
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

PAGANELLI R¹,QUINTI I¹,FAGIOLO U²,COSSARIZZA A³,ORTOLANI C⁴,GUERRA E¹,SANSONI P⁵,PUCILLO L P⁶,SCALA E¹,COZZI E²,BERTOLLO L²,MONTI D³,FRANCESCHI C³

Affiliation:

1. Department of Allergy and Clinical Immunology, University La Sapienza, Rome

2. Institute of Internal Medicine, University of Padova, Padova

3. Institute of General Pathology, University of Modena, Modena

4. Laboratory, S.S. Giovanni and Paolo Hospital, Venice

5. Institute of Clinical Medicine, University of Parma, Parma

6. Laboratory, St. Peter's Hospital, Rome, Italy

Abstract

SUMMARY The study of 87 adults of different ages, including 15 centenarians, selected for their healthy status, showed that profound changes of humoral immunity occur throughout life. In particuIar, a statistically significant age-reIated increase of the serum level of immunoglobulin cIasses (IgG and IgA but not IgM) and IgG subcIasses (IgG1, 2 and 3, but not IgG4) was detected. A parallel age-related decrease of circuIating B cells was also observed. The hypothesis of a complex derangement of B cell function and/or compartmentalization with age is put forward, together with the proposal that healthy centenarians (as representative of successful ageing) may be helpful in identifying the physiological age-reIated modifications of the immune system.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/90/2/351/42212596/j.1365-2249.1992.tb07954.x.pdf

Reference23 articles.

1. Thymic hormone deficiency in normal ageing and Down's syndrome: is there a primary failure of the thymus;Fabris;Lancet,1984

2. Alteration of the capping phenomenon on lymphocytes from aged and Down's syndrome subjects;Chiricolo;Gerontology,1984

3. The cellular and subcellular bases of immunosenescence;Thoman;Adv Immunol,1990

4. Lymphocyte phytohemagglutinin responsiveness, immunoglobulins and auto-antibodies in aging humans;Hallgren;J Immunol,1973

5. Longitudinal changes in serum immunoglobulin levels in older humans;Buckley;Fed Proc,1974

Cited by 118 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Immunotherapy in Older Patients with Cancer: A Narrative Review;International Journal of General Medicine;2024-01

2. Ocrelizumab associates with reduced cerebrospinal fluid B and CD20dim CD4+ T cells in primary progressive multiple sclerosis;Brain Communications;2023-12-28

3. Memory B cell development elicited by mRNA booster vaccinations in the elderly;Journal of Experimental Medicine;2023-06-27

4. Immunoglobulin G glycans – Biomarkers and molecular effectors of aging;Clinica Chimica Acta;2022-10

5. Immunosenescence, aging and successful aging;Frontiers in Immunology;2022-08-02