Anti‐renal interstitial fibrosis effect of norcantharidin is exerted through inhibition of PP2Ac‐mediated C‐terminal phosphorylation of Smad3-Reference-Cited by-同舟云学术

Anti‐renal interstitial fibrosis effect of norcantharidin is exerted through inhibition of PP2Ac‐mediated C‐terminal phosphorylation of Smad3

Published:2020-09-07 Issue:2 Volume:97 Page:293-304
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Luo Han‐wen¹,Yin Dan‐dan²,Xiao Zheng¹,Wen Lu¹,Liao Ying‐jun¹,Tang Cheng‐yuan¹,Zeng Dong¹,Xiao Heng‐ting¹,Li Ying¹^ORCID

Affiliation:

1. Department of Nephrology Key Laboratory of Kidney Disease and Blood Purification in Hunan The Second Xiangya Hospital Central South University Hunan China

2. Jiangsu Province Hospital Nanjing Medical University First Affiliated Hospital Nanjing Jiangsu China

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.13781

Reference46 articles.

1. GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β–Induced Smad3 Phosphorylation

2. PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1

3. Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment

4. Norcantharidin analogues: a patent review (2006 – 2010)

5. Blocking Tyr265 nitration of protein phosphatase 2A attenuates nitrosative stress–induced endothelial dysfunction in renal microvessels

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