Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity

Author:

El‐Boraie Ahmed1,Taghavi Taraneh1,Chenoweth Meghan J.1,Fukunaga Koya2,Mushiroda Taisei2,Kubo Michiaki2,Lerman Caryn3,Nollen Nicole L.4,Benowitz Neal L.5ORCID,Tyndale Rachel F.16ORCID

Affiliation:

1. Department of Pharmacology and ToxicologyUniversity of Toronto Toronto M5S 1A8 Canada

2. Center for Integrative Medical SciencesRIKEN Yokohama Kanagawa 230‐0045 Japan

3. Department of Psychiatry and Abramson Cancer CenterUniversity of Pennsylvania Philadelphia 19104 Pennsylvania

4. Department of Preventive Medicine and Public HealthUniversity of Kansas Kansas City 66160 Kansas

5. Departments of Medicine and Biopharmaceutical Sciences, Division of Clinical Pharmacology and Experimental Therapeutics, Medical Services and Center for Tobacco Control Research and EducationUniversity of California San Francisco 94110 California

6. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Division of Brain and Therapeutics, Department of PsychiatryUniversity of Toronto Toronto M6J 1H4 Canada

Funder

Ontario Ministry of Research, Innovation and Science

Canada Foundation for Innovation

Centre for Addiction and Mental Health Foundation

Canadian Institutes of Health Research

National Institutes of Health

Publisher

Wiley

Subject

Psychiatry and Mental health,Pharmacology,Medicine (miscellaneous)

Reference50 articles.

1. Nicotine Chemistry, Metabolism, Kinetics and Biomarkers

2. Role of human cytochrome P4502A6 in C‐oxidation of nicotine;Nakajima M;Drug Metab Dispos,1996

3. Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity*1

4. Characterization of CYP2A6 involved in 3′‐hydroxylation of cotinine in human liver microsomes;Nakajima M;J Pharmacol Exp Ther,1996

5. Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers

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