Discovery and Design of Novel HSP90 Inhibitors Using Multiple Fragment-based Design Strategies-Reference-Cited by-同舟云学术

Discovery and Design of Novel HSP90 Inhibitors Using Multiple Fragment-based Design Strategies

Published:2007-07 Issue:1 Volume:70 Page:1-12
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Design

Author:

Huth Jeffrey R.,Park Chang,Petros Andrew M.,Kunzer Aaron R.,Wendt Michael D.,Wang Xilu,Lynch Christopher L.,Mack Jamey C.,Swift Kerry M.,Judge Russell A.,Chen Jun,Richardson Paul L.,Jin Sha,Tahir Stephen K.,Matayoshi Edward D.,Dorwin Sarah A.,Ladror Uri S.,Severin Jean M.,Walter Karl A.,Bartley Diane M.,Fesik Stephen W.,Elmore Steven W.,Hajduk Philip J.

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference27 articles.

1. Hsp90: A Novel Target for Cancer Therapy

2. Heat Shock Protein 90: A Unique Chemotherapeutic Target

3. Navigating the Chaperone Network: An Integrative Map of Physical and Genetic Interactions Mediated by the Hsp90 Chaperone

4. A biochemical rationale for the anticancer effects of Hsp90 inhibitors: Slow, tight binding inhibition by geldanamycin and its analogues

5. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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