Identification of Allosteric PIF-Pocket Ligands for PDK1 using NMR-Based Fragment Screening and1H-15N TROSY Experiments-Reference-Cited by-同舟云学术

Identification of Allosteric PIF-Pocket Ligands for PDK1 using NMR-Based Fragment Screening and1H-15N TROSY Experiments

Published:2009-02 Issue:2 Volume:73 Page:179-188
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:

Author:

Stockman Brian J.,Kothe Michael,Kohls Darcy,Weibley Laura,Connolly Brendan J.,Sheils Alissa L.,Cao Qing,Cheng Alan C.,Yang Lily,Kamath Ajith V.,Ding Yuan-Hua,Charlton Maura E.

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference36 articles.

1. The phosphoinositide 3-kinase pathway;Cantley;Science,2002

2. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism;Engelman;Nat Rev Gen,2006

3. Targeting the PI3K-Akt pathway in human cancer: rationale and promise;Luo;Cancer Cell,2003

4. Critical nodes in signalling pathways: insights into insulin action;Taniguchi;Nat Rev Mol Cell Biol,2006

5. The role of phosphoinositide 3-kinase lipid products in cell function;Rameh;J Biol Chem,1999

Cited by 58 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The choreography of protein kinase PDK1 and its diverse substrate dance partners;Biochemical Journal;2023-10-04

2. Insilico molecular modelling to identify PDK-1 targeting agents based on its protein–protein docking interaction;Journal of Biomolecular Structure and Dynamics;2023-08-30

3. Multimodal generative neural networks and molecular dynamics based identification of PDK1 PIF-pocket modulators;Molecular Systems Design & Engineering;2022

4. Noncellular screening for the discovery of protein–protein interaction modulators;Drug Discovery Today;2020-09

5. Fluorine NMR functional screening: from purified enzymes to human intact living cells;Journal of Biomolecular NMR;2020-04-28