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Synthesis and Immunomodulation of Human Lymphocyte Proliferation and Cytokine (Interferon-γ) Production of Four Novel Malonitrilamides

  • Published:2009-06 Issue:6 Volume:73 Page:668-673
  • ISSN:1747-0277
  • Container-title:Chemical Biology & Drug Design
  • language:en
  • Short-container-title:

Author:

Hadizadeh Farzin,Moallem Seyed Adel,Jaafari Mahmoud Reza,Shahab Mahdi,Alahyari Maryam,Rameshrad Maryam,Samiei Afshin

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference20 articles.

1. Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide;Greene;Biochem Pharmacol,1995

2. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis;Cherwinski;J Pharmacol Exp Ther,1995

3. Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis;Cutolo;Ann Rheum Dis,2003

4. Experiences with leflunomide in solid organ transplantation;Williams;Transplantation,2002

5. A 771726, the active metabolite of leflunomide, inhibits TNF-alpha and IL-1 from Kupffer cells;Yao;Inflammation,2004
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