Pickering emulsion of pepper essential oil stabilized by Octenyl succinic acid starch: Characterization, in vitro release and anticancer activity

Author:

Wang Yitong123,Jin Liu4,Xie Baoguo5,Chen Xiaoai12,Xu Fei12,Zhu Kexue12,Wang Ping3,Zhang Yanjun12ORCID

Affiliation:

1. Spice and Beverage Research Institute Chinese Academy of Tropical Agricultural Sciences Wanning Hainan China

2. Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province Wanning Hainan China

3. College of Life Science Northeast Forestry University Harbin Heilongjiang China

4. Women's & Children's Hospital of Wanning Wanning Hainan China

5. Reproductive medicine Center the First Affiliated Hospital of Hainan Medical University Haikou Hainan China

Abstract

AbstractUnder high humidity and high temperature conditions, the quality of pepper essential oil easily deteriorates, and the oxidation of oil restricts its application, especially for the insolubility in water. This study investigated pepper essential oil encapsulated in Pickering emulsion with octenyl succinic acid starch, which was effectively able to reduce 100 times of the release rate. The smooth surface and complete particles of the emulsion were observed and no new chemical bonds were formed. The minimum particle sizes were 2.05 µm and 1.89 µm, when the Pickering emulsion was set to different storage conditions at pH 5 and 0.1 M NaCl, respectively. During gastrointestinal digestion, the release of essential oils was effectively delayed in the Pickering emulsion and the digestibility of the emulsion was 16.93% in 120 min. Compared with untreated cells, Pickering emulsion can effectively inhibit the proliferation of MCF‐7 (52.71%). All these results indicate that OSA starch stabilized pepper essential oil can effectively increase solubility, improve stability, and expand the application range. Therefore, it can provide a theoretical basis for applications of pepper essential oil, especially for the functional drug application.

Publisher

Wiley

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