Affiliation:
1. College of Life Sciences Inner Mongolia Agricultural University Hohhot China
2. School of Life Sciences Inner Mongolia University Hohhot China
3. College of Veterinary Medicine Inner Mongolia Agricultural University Hohhot China
Abstract
AbstractThe stems of Cynomorium songaricum are used in traditional Chinese medicine as a tonic and also used locally as a food material and livestock feed. It is known that some of the falvan‐3‐ol monomers and dimers that entered the milk of dairy sheep fed with C. songaricum stems are biotransformation products of the original flavan‐3‐ol polymers in C. songaricum stems. This study was performed to investigate the biotransformation process of the flavan‐3‐ols in dairy sheep and to evaluate the bioactivities. The results showed that procyanidin A2 and epicatechin could be released from the polymeric flavan‐3‐ols of C. songaricum through rumen microbial metabolism. On traumatic and lipopolysaccharide (LPS)‐induced inflammation models of Tg (mpx: EGFP) zebrafish larvae and LPS‐induced liver injury models of Tg (fabp10a: DsRed) zebrafish larvae, the milk from sheep fed with C. songaricum stems showed stronger anti‐inflammatory and hepatoprotective activities compared to blank milk. The absorbed chemical constituents of C. songaricum stems and the metabolites also exhibited anti‐inflammatory and hepatoprotective activities, with the dimeric flavan‐3‐ols being more effective than the monomers. The milk, the absorbed chemical constituents of C. songaricum stems, and the metabolites alleviated the increased level of reactive oxygen species induced by LPS in zebrafish larvae.Practical ApplicationThis study found that C. songaricum stems as livestock feed could produce milk that has a beneficial impact on consumer and livestock health in terms of anti‐inflammation and hepatoprotection.
Reference16 articles.
1. Effects of three kinds of diets without antibiotics on growth performance, slaughter performance, meat quality and flavor of Duroc and Bamei cross finishing pigs;Chai M.;Chinese Journal of Animal Nutrition,2020
2. Dietary flavonoids: Role of (−)-epicatechin and related procyanidins in cell signaling