Cardiac remodelling in non‐alcoholic fatty liver disease in the general population

Author:

Kostka Frederik1ORCID,Ittermann Till2,Groß Stefan34,Laqua Fabian Christopher5ORCID,Bülow Robin14,Völzke Henry2,Dörr Marcus34,Kühn Jens Peter6ORCID,Markus Marcello Ricardo Paulista37,Kromrey Marie‐Luise1

Affiliation:

1. Institute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald Greifswald Germany

2. Department of Study of Health in Pomerania/Clinical‐Epidemiological Research, Institute for Community Medicine University Medicine Greifswald Greifswald Germany

3. Department of Internal Medicine B University Medicine Greifswald Greifswald Germany

4. German Centre for Cardiovascular Research (DZHK) Partner Site Greifswald Greifswald Germany

5. Department of Diagnostic and Interventional Radiology University Hospital Wuerzburg Wuerzburg Germany

6. Institute and Policlinic for Diagnostic and Interventional Radiology University Hospital, Carl Gustav Carus University, TU Dresden Dresden Germany

7. German Center for Diabetes Research (DZD) Partner Site Greifswald Greifswald Germany

Abstract

AbstractBackground and AimsNon‐alcoholic fatty liver disease (NAFLD) is associated with increased risk for cardiovascular disease. Our study investigates the contribution of NAFLD to changes in cardiac structure and function in a general population.MethodsOne thousand ninety‐six adults (49.3% female) from the Study of Health in Pomerania underwent magnetic resonance imaging including cardiac and liver imaging. The presence of NAFLD by proton density fat fraction was related to left cardiac structure and function. Results were adjusted for clinical confounders using multivariable linear regression model.ResultsThe prevalence for NAFLD was 35.9%. In adjusted multivariable linear regression models, NAFLD was positively associated with higher left ventricular mass index (β = 0.95; 95% confidence interval (CI): 0.45; 1.45), left ventricular concentricity (β = 0.043; 95% CI: 0.031; 0.056), left ventricular end‐diastolic wall thickness (β = 0.29; 95% CI: 0.20; 0.38), left atrial end‐diastolic volume index (β = 0.67; 95% CI: 0.01; 1.32) and inversely associated with left ventricular end‐diastolic volume index (β = −0.78; 95% CI: −1.51; −0.05). When stratified by sex, we only found significant positive associations of NAFLD with left ventricular mass index, left atrial end‐diastolic volume index, left ventricular cardiac output and an inverse association with global longitudinal strain in women. In contrast, men had an inverse association with left ventricular end‐diastolic volume index and left ventricular stroke volume. Higher liver fat content was stronger associated with higher left ventricular mass index, left ventricular concentricity and left ventricular end‐diastolic wall thickness.ConclusionNAFLD is associated with cardiac remodelling in the general population showing sex specific patterns in cardiac structure and function.

Publisher

Wiley

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