Elevated interleukin-27 levels in human neonatal macrophages regulate indoleamine dioxygenase in a STAT-1 and STAT-3-dependent manner

Author:

Jung Joo-Yong1,Gleave Parson Madeline2,Kraft Jennifer D.3,Lyda Logan2,Kobe Brianna2,Davis Celestia45,Robinson Jembber3,Peña Maria Marjorette O.45,Robinson Cory M.2

Affiliation:

1. Department of Biology; Briar Cliff University; Sioux City IA USA

2. Biomedical Sciences Department; West Virginia School of Osteopathic Medicine; Lewisburg WV USA

3. Department of Pathology Microbiology and Immunology; University of South Carolina School of Medicine; Columbia SC USA

4. Department of Biological Sciences; University of South Carolina; Columbia SC USA

5. Center for Colon Cancer Research; University of South Carolina; Columbia SC USA

Funder

University of South Carolina School of Medicine

West Virginia School of Osteopathic Medicine

NIH/NIAID

Institutional Development Award (IDeA)

NIH/NIGMS

NIH/NIGMS COBRE

NIH/NCI

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference62 articles.

1. World Health Organization Infant mortality http://www.who.int/gho/child_health/mortality/neonatal_infant_text/en/index.html

2. 4 million neonatal deaths: when? where? why?;Lawn;Lancet,2005

3. Neonatal macrophages express elevated levels of interleukin-27 that oppose immune responses;Kraft;Immunology,2013

4. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naïve CD4+ T cells;Pflanz;Immunity,2002

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