Enduring efficacy and tolerability of daratumumab in combination with lenalidomide and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma ( GEN 503): final results of an open‐label, phase 1/2 study

Author:

Plesner Torben1ORCID,Arkenau Hendrik‐Tobias2,Gay Francesca3,Minnema Monique C.4,Boccadoro Mario3,Moreau Philippe5ORCID,Cavenagh Jamie6,Perrot Aurore7,Laubach Jacob P.8ORCID,Krejcik Jakub1,Ahmadi Tahamtan9,Boer Carla10,Chen Diana11,Chiu Christopher12,Schecter Jordan M.13,Richardson Paul G.8ORCID

Affiliation:

1. Vejle Hospital and University of Southern Denmark VejleDenmark

2. Sarah Cannon Research Institute University College London Cancer Institute LondonUnited Kingdom

3. Myeloma Unit Division of Hematology University of Torino TorinoItaly

4. Department of Hematology UMC Utrecht Cancer Centre UtrechtThe Netherlands

5. Department of Hematology University Hospital Hôtel‐Dieu NantesFrance

6. Department of Haemato‐Oncology St Bartholomew's Hospital Barts Health NHS Trust LondonUnited Kingdom

7. Hematology Department University Hospital Vandoeuvre Les NancyFrance

8. The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center Department of Medical Oncology Dana‐Farber Cancer Institute Harvard Medical School Boston MA USA

9. Genmab US Inc. Princeton NJUSA

10. Janssen Biologics Leiden The Netherlands

11. Janssen Research & Development Shanghai China

12. Janssen Research & Development Spring House PA USA

13. Janssen Research & Development Raritan NJ USA

Funder

Janssen Research and Development

Publisher

Wiley

Subject

Hematology

Reference6 articles.

1. Lenalidomide plus Dexamethasone for Relapsed or Refractory Multiple Myeloma

2. Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma

3. Phase 1/2 study of daratumumab, lenalidomide, and dexamethasone for relapsed multiple myeloma

4. Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1

5. US Department of Health and Human Services National Institutes of Health & National Cancer Institute. (2010)Common Terminology Criteria for Adverse Events (CTCAE). Version 4.03.https://www.eortc.be/services/doc/ctc/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf(accessed July 11 2018).

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