An intercountry comparison of the impact of the paediatric live attenuated influenza vaccine (LAIV) programme across the UK and the Republic of Ireland (ROI), 2010 to 2017

Author:

Sinnathamby Mary A.1ORCID,Warburton Fiona1ORCID,Reynolds Arlene J.2,Cottrell Simon3,O'Doherty Mark4,Domegan Lisa5ORCID,O'Donnell Joan5,Johnston Jillian4,Yonova Ivelina67,Elgohari Suzanne1,Boddington Nicola L.1,Andrews Nick1,Ellis Joanna1,de Lusignan Simon678ORCID,McMenamin Jim2,Pebody Richard G.1

Affiliation:

1. UK Health Security Agency London UK

2. Public Health Scotland Glasgow UK

3. Public Health Wales Cardiff UK

4. Public Health Agency Northern Ireland Belfast UK

5. Health Service Executive‐Health Protection Surveillance Centre Dublin Ireland

6. Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) London UK

7. University of Surrey Guilford UK

8. University of Oxford UK

Abstract

AbstractBackgroundThe universal paediatric live attenuated influenza vaccine (LAIV) programme commenced in the United Kingdom (UK) in 2013/2014. Since 2014/2015, all pre‐school and primary school children in Scotland and Northern Ireland have been offered the vaccine. England and Wales incrementally introduced the programme with additional school age cohorts being vaccinated each season. The Republic of Ireland (ROI) had no universal paediatric programme before 2017. We evaluated the potential population impact of vaccinating primary school‐aged children across the five countries up to the 2016/2017 influenza season.MethodsWe compared rates of primary care influenza‐like illness (ILI) consultations, confirmed influenza intensive care unit (ICU) admissions, and all‐cause excess mortality using standardised methods. To further quantify the impact, a scoring system was developed where each weekly rate/z‐score was scored and summed across each influenza season according to the weekly respective threshold experienced in each country.ResultsResults highlight ILI consultation rates in the four seasons' post‐programme, breached baseline thresholds once or not at all in Scotland and Northern Ireland; in three out of the four seasons in England and Wales; and in all four seasons in ROI. No differences were observed in the seasons' post‐programme introduction between countries in rates of ICU and excess mortality, although reductions in influenza‐related mortality were seen. The scoring system also reflected similar results overall.ConclusionsFindings of this study suggest that LAIV vaccination of primary school age children is associated with population‐level benefits, particularly in reducing infection incidence in primary care.

Publisher

Wiley

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,Pulmonary and Respiratory Medicine,Epidemiology

Reference30 articles.

1. Public Health England.Influenza: the green book Chapter 19. Available from:https://www.gov.uk/government/publications/influenza-the-green-book-chapter-19

2. Health Service Executive—Ireland.Immunisation guidelines: influenza Chapter 11. Available from:https://www.hse.ie/eng/health/immunisation/hcpinfo/guidelines/chapter11.pdf

3. Joint Committee on Vaccination and Immunisation.Meeting minutes—5 October 2011. London. Available from:http://webarchive.nationalarchives.gov.uk/20120907151157/http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@ab/documents/digitalasset/dh_133598.pdf

4. Assessing Optimal Target Populations for Influenza Vaccination Programmes: An Evidence Synthesis and Modelling Study

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