A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers

Author:

Okour Malek1ORCID,Derimanov Geo2,Barnett Rodger3,Fernandez Esther4,Ferrer Santiago4,Gresham Stephanie5,Hossain Mohammad1,Gamo Francisco-Javier4,Koh Gavin6,Pereira Adrian7,Rolfe Katie8,Wong Deborah9,Young Graeme7,Rami Harshad6,Haselden John4

Affiliation:

1. Clinical Pharmacology Modeling and Simulation (CPMS); GlaxoSmithKline; King of Prussia PA USA

2. Discovery Medicine, Diseases of the Developing World; GlaxoSmithKline; Collegeville PA USA

3. Drug Product Design and Development (DPDD); GlaxoSmithKline; Ware Herts UK

4. Malaria DPU, Tres Cantos Medicines Development Campus; GlaxoSmithKline; Tres Cantos Spain

5. Mechanistic Safety and Disposition; GlaxoSmithKline; Ware UK

6. Diseases of the Developing World; GlaxoSmithKline; Stockley Park Uxbridge UK

7. Bioanalysis, Immunogenicity and Biomarkers (BIB); GlaxoSmithKline; Ware UK

8. Statistics, Programming and Data Strategy (SPDS); GlaxoSmithKline; Stockley Park Uxbridge UK

9. Clinical Pharmacology Science & Study Operations (CPSSO); GlaxoSmithKline; Stevenage Hertfordshire UK

Funder

GlaxoSmithKline

Medicines for Malaria Venture

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference30 articles.

1. World Health Organization-world malaria report 2016 http://apps.who.int/iris/bitstream/10665/252038/1/9789241511711-eng.pdf?ua=1

2. Artemisinin resistance in Plasmodium falciparum malaria;Dondorp;N Engl J Med,2009

3. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study;Phyo;Lancet,2012

4. Evidence of artemisinin-resistant malaria in western Cambodia;Noedl;N Engl J Med,2008

5. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria;Ariey;Nature,2014

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