CIA‐II is associated with lower‐grade glioma survival and cell proliferation

Author:

Xiao Feng1234ORCID,Zhu Hong1234,Guo Yun1234,Zhang Zhe1234,Sun Gufeng1234,Xiao Yao1234,Hu Guowen1,Huang Kai1234,Guo Hua1234

Affiliation:

1. Department of Neurosurgery The Second Affiliated Hospital of Nanchang University Nanchang China

2. Jiangxi Key Laboratory of Neurological Tumors and Cerebrovascular Diseases Nanchang China

3. Jiangxi Health Commission Key Laboratory of Neurological Medicine Nanchang China

4. Institute of Neuroscience Nanchang University Nanchang China

Abstract

AbstractBackgroundThe role of CIA‐II has been clarified in several types of tumors; however, whether dysregulated CIA‐II expression is also involved in the pathophysiology of lower‐grade glioma (LGG) remains undisclosed.MethodsA comprehensive pan‐cancer analysis of the expression patterns and prognostic significance of CIA‐II in miscellaneous tumors was undertaken. Subsequently, a detailed bioinformatics analysis was executed to identify putative correlations between CIA‐II expression and clinical features, prognosis, biological functions, immunological characteristics, genomic alterations, and chemotherapeutics in LGG. In vitro studies were implemented to examine the potential roles of CIA‐II in LGG.ResultsCIA‐II expression was found to be abnormally elevated in a variety of tumors, including LGG. Additionally, patients with LGG with higher CIA‐II expression owned worse prognosis. Importantly, the results declared that CIA‐II expression was an independent prognostic indicator for LGG. Moreover, the expression of CIA‐II was tightly interrelated with immune cell infiltration, gene mutations, and chemotherapeutics in LGG. In vitro studies revealed that CIA‐II was increased and strongly related to the cell proliferation in LGG.ConclusionCIA‐II may be an independent prognostic factor and a serviceable therapeutic target in LGG.

Funder

Education Department of Jiangxi Province

Graduate Innovative Special Fund Projects of Jiangxi Province

Health Commission of Jiangxi Province

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology (medical),Physiology (medical),Psychiatry and Mental health,Pharmacology

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