Affiliation:
1. Department of Digestive Oncology Guangxi Medical University Cancer Hospital Nanning Guangxi China
2. Department of Hepatobiliary Surgery Guangxi Medical University Cancer Hospital Nanning Guangxi China
Abstract
AbstractNetrins, a family of secreted and membrane‐associated proteins, can regulate axonal guidance, morphogenesis, angiogenesis, cell migration, cell survival, and tumorigenesis. Four secreted netrins (netrin 1, 3, 4 and 5) and two glycosylphosphatidylinositols‐anchored membrane proteins, netrin‐G1 and G2, have been identified in mammals. Netrins and their receptors can serve as a biomarker and molecular therapeutic target for pathological differentiation, diagnosis and prognosis of malignant cancers. We review here the potential roles of the netrins family and their receptors in cancer.
Funder
National Natural Science Foundation of China