LncRNAs expression profile in a family household cluster of COVID‐19 patients

Author:

Iancu Iulia Virginia1ORCID,Diaconu Carmen Cristina1ORCID,Plesa Adriana1,Fudulu Alina1,Albulescu Adrian12,Neagu Ana Iulia13,Pitica Ioana Madalina1,Dragu Laura Denisa1,Bleotu Coralia1ORCID,Chivu‐Economescu Mihaela1,Matei Lilia1,Mambet Cristina1ORCID,Nedeianu Saviana1,Popescu Corneliu Petru34,Sultana Camelia13,Ruta Simona Maria13,Botezatu Anca1ORCID

Affiliation:

1. Stefan S Nicolau Institute of Virology Bucharest Romania

2. Department of Pharmacology National Institute for Chemical Pharmaceutical Research and Development Bucharest Romania

3. Carol Davila University of Medicine and Pharmacy Bucharest Romania

4. Dr Victor Babes Infectious and Tropical Diseases Clinical Hospital Bucharest Romania

Abstract

AbstractMore than 3 years after the start of SARS‐CoV‐2 pandemic, the molecular mechanisms behind the viral pathogenesis are still not completely understood. Long non‐coding RNAs (lncRNAs), well‐known players in viral infections, can represent prime candidates for patients' risk stratification. The purpose of the current study was to investigate the lncRNA profile in a family cluster of COVID‐19 cases with different disease progression, during the initial wave of the pandemic and to evaluate their potential as biomarkers for COVID‐19 evolution. LncRNA expression was investigated in nasopharyngeal swabs routinely collected for diagnosis. Distinct expression patterns of five lncRNAs (HOTAIR, HOTAIRM1, TMEVPG1, NDM29 and snaR) were identified in all the investigated cases, and they were associated with disease severity. Additionally, a significant increase in the expression of GAS5‐family and ZFAS1 lncRNAs, which target factors involved in the inflammatory response, was observed in the sample collected from the patient with the most severe disease progression. An lncRNA prognostic signature was defined, opening up novel research avenues in understanding the interactions between lncRNAs and SARS‐CoV‐2.

Publisher

Wiley

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