Unusual case of extramammary Paget disease of the oral mucosa: A case report and literature review

Author:

Eilers Grant1ORCID,Jordan Richard C.12

Affiliation:

1. Department of Pathology University of California, San Francisco San Francisco California USA

2. UCSF Dermatopathology & Oral Pathology Service University of California, San Francisco San Francisco California USA

Abstract

AbstractPaget disease is an intraepithelial neoplastic proliferation, commonly occurring in the breast and apocrine‐rich areas, often associated with an underlying internal malignancy. Extramammary Paget disease (EMPD) of the oral cavity is exceedingly rare, with only eight reported cases, four of which were associated with an underlying internal malignancy. Here, we report a case of oral EMPD involving the buccal mucosa and gingiva of an 81‐year‐old male with no known underlying internal malignancy. The Paget cells were positive for CK7, CK20, CAM5.2, and androgen receptor, but negative for SOX10 and p63. The immunophenotype, association with internal malignancies, and treatment approaches for oral EMPD are reviewed.

Publisher

Wiley

Reference47 articles.

1. On Disease of the Mammary Areola Preceding Cancer of the Mammary Gland

2. Mammary Paget's disease and associated carcinoma. An immunohistochemical study;Cohen C;Arch Pathol Lab Med,1993

3. Paget's disease affecting the scrotum and penis;Crocker HR;Trans Pathol Soc Lond,1889

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