Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells
Author:
Affiliation:
1. Laboratory of Experimental Immunology; WPI Immunology Frontier Research Center; Osaka University; Osaka Japan
2. Department of Experimental Pathology; Institute for Frontier Medical Sciences; Kyoto University; Kyoto Japan
Publisher
Wiley
Subject
Immunology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/imr.12174/fullpdf
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3. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases;Sakaguchi;J Immunol,1995
4. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells;Fontenot;Nat Immunol,2003
5. Control of regulatory T cell development by the transcription factor Foxp3;Hori;Science,2003
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