Bone marrow stroma protects myeloma cells from cytotoxic damage via induction of the oncoprotein MUC1

Author:

Bar-Natan Michal1,Stroopinsky Dina1,Luptakova Katarina1,Coll Maxwell D.1,Apel Arie1,Rajabi Hasan2,Pyzer Athalia R.1,Palmer Kristen1,Reagan Michaela R.3,Nahas Myrna R.1,Karp Leaf Rebecca1,Jain Salvia1,Arnason Jon1,Ghobrial Irene M.3,Anderson Kenneth C.2,Kufe Donald2,Rosenblatt Jacalyn1,Avigan David1

Affiliation:

1. Beth Israel Deaconess Medical Center; Harvard Medical School; Boston MA USA

2. Dana Farber Cancer Institute; Harvard Medical School; Boston MA USA

3. Jerome Lipper Multiple Myeloma Center; Department of Medical Oncology; Dana Farber Cancer Institute; Harvard Medical School; Boston MA USA

Publisher

Wiley

Subject

Hematology

Reference49 articles.

1. MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor;Ahmad;Cancer Research,2009

2. MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop;Ahmad;Science Signalling,2011

3. Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells;Alam;Oncotarget,2014

4. MUC1 (EMA) expressing plasma cells in bone marrow infiltrated by plasma cell myeloma;Baldus;Histology and Histopathology,2007

5. Inhibition of MUC1-C suppresses MYC expression and attenuates malignant Growth in KRAS mutant lung adenocarcinomas;Bouillez;Cancer Research,2016

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