Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease-Reference-Cited by-同舟云学术

Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease

Published:2016-04 Issue:2 Volume:101 Page:194-209
ISSN:0950-382X
Container-title:Molecular Microbiology
language:en
Short-container-title:Molecular Microbiology

Author:

Famulla Kirsten¹,Sass Peter¹,Malik Imran¹,Akopian Tatos²,Kandror Olga²,Alber Marina³,Hinzen Berthold⁴,Ruebsamen‐Schaeff Helga⁵,Kalscheuer Rainer³,Goldberg Alfred L.²,Brötz‐Oesterhelt Heike¹

Affiliation:

1. Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection MedicineUniversity of TuebingenTuebingen Germany

2. Department of Cell BiologyHarvard Medical SchoolBoston MA USA

3. Institute for Medical Microbiology and Hospital Hygiene, University of DuesseldorfDuesseldorf Germany

4. Bayer Pharma AGWuppertal Germany

5. AiCuris GmbH & Co. KGWuppertal Germany

Funder

German Research Foundation

Jürgen Manchot Foundation to R.K

Publisher

Wiley

Subject

Molecular Biology,Microbiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.13362

Reference66 articles.

1. The active ClpP protease fromM. tuberculosisis a complex composed of a heptameric ClpP1 and a ClpP2 ring

2. Structural determinants stabilizing the axial channel of ClpP for substrate translocation

3. REQUIREMENTS FOR TRANSFORMATION IN BACILLUS SUBTILIS

4. ClpXP, an ATP-powered unfolding and protein-degradation machine

5. Rising standards for tuberculosis drug development

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