A systems‐level analysis highlights microglial activation as a modifying factor in common epilepsies

Author:

Altmann Andre1ORCID,Ryten Mina2,Di Nunzio Martina3,Ravizza Teresa3,Tolomeo Daniele3,Reynolds Regina H.2,Somani Alyma4,Bacigaluppi Marco5,Iori Valentina3,Micotti Edoardo3,Di Sapia Rossella3ORCID,Cerovic Milica3,Palma Eleonora6,Ruffolo Gabriele6,Botía Juan A.27,Absil Julie8,Alhusaini Saud910,Alvim Marina K. M.11,Auvinen Pia1213,Bargallo Nuria1415,Bartolini Emanuele1617,Bender Benjamin18ORCID,Bergo Felipe P. G.11,Bernardes Tauana11,Bernasconi Andrea19,Bernasconi Neda19,Bernhardt Boris C.20,Blackmon Karen21,Braga Barbara11,Caligiuri Maria Eugenia22,Calvo Anna14,Carlson Chad2324,Carr Sarah J. A.25,Cavalleri Gianpiero L.926,Cendes Fernando11,Chen Jian27,Chen Shuai2829,Cherubini Andrea22,Concha Luis30,David Philippe8,Delanty Norman92631,Depondt Chantal32,Devinsky Orrin33,Doherty Colin P.2634,Domin Martin35,Focke Niels K.3637,Foley Sonya38,Franca Wendy11,Gambardella Antonio2239,Guerrini Renzo16,Hamandi Khalid3840,Hibar Derrek P.41,Isaev Dmitry41,Jackson Graeme D.4243,Jahanshad Neda41,Kälviäinen Reetta1213,Keller Simon S.44,Kochunov Peter45,Kotikalapudi Raviteja183536,Kowalczyk Magdalena A.42,Kuzniecky Ruben46,Kwan Patrick47,Labate Angelo2239,Langner Soenke35,Lenge Matteo16,Liu Min19,Martin Pascal36,Mascalchi Mario48,Meletti Stefano49,Morita‐Sherman Marcia E.1150,O'Brien Terence J.4751,Pariente Jose C.14,Richardson Mark P.2552,Rodriguez‐Cruces Raul2030,Rummel Christian53,Saavalainen Taavi1354,Semmelroch Mira K.4243,Severino Mariasavina55ORCID,Striano Pasquale56,Thesen Thomas23,Thomas Rhys H.57,Tondelli Manuela50,Tortora Domenico55,Vaudano Anna Elisabetta49,Vivash Lucy4758,Podewils Felix59,Wagner Jan60,Weber Bernd61,Wiest Roland53,Yasuda Clarissa L.11,Zhang Guohao62,Zhang Junsong2829,Leu Costin636465,Avbersek Andreja64,Thom Maria465ORCID,Whelan Christopher D.941,Thompson Paul41,McDonald Carrie R.6667,Vezzani Annamaria3,Sisodiya Sanjay M.6568, ,

Affiliation:

1. Centre for Medical Image Computing University College London London UK

2. Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK

3. Department of Neuroscience Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy

4. Division of Neuropathology UCL Queen Square Institute of Neurology London UK

5. Department of Neurology San Raffaele Scientific Institute and Vita Salute San Raffaele University Milan Italy

6. Department of Physiology and Pharmacology Sapienza University of Rome Rome Italy

7. Departamento de Ingeniería de la Información y las Comunicaciones Universidad de Murcia Murcia Spain

8. Department of Radiology Hôpital Erasme, Universite Libre de Bruxelles Brussels Belgium

9. Department of Molecular and Cellular Therapeutics Royal College of Surgeons in Ireland Dublin Ireland

10. Neurology Department Yale University School of Medicine New Haven CT USA

11. Department of Neurology University of Campinas Campinas Brazil

12. Epilepsy Center, Department of Neurology Kuopio University Kuopio Finland

13. Institute of Clinical Medicine, Neurology University of Eastern Finland Kuopio Finland

14. Magnetic Resonance Image Core Facility IDIBAPS Barcelona Spain

15. Centre de Diagnostic Per la Imatge (CDIC) Hospital Clinic Barcelona Spain

16. Pediatric Neurology Unit Children's Hospital A. Meyer‐University of Florence Florence Italy

17. Neurology Unit USL Centro Toscana, Nuovo Ospedale Santo Stefano Prato Italy

18. Department of Diagnostic and Interventional Neuroradiology University of Tübingen Tübingen Germany

19. Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital McGill University Montreal Quebec Canada

20. Multimodal Imaging and Connectome Analysis Lab, Montreal Neurological Institute and Hospital McGill University Montreal Quebec Canada

21. Psychiatry and Psychology Mayo Clinic Jacksonville FL USA

22. Neuroscience Research Center, Department of Medical and Surgical Sciences University “Magna Græcia” of Catanzaro Catanzaro Italy

23. Comprehensive Epilepsy Center, Department of Neurology New York University School of Medicine New York New York USA

24. Department of Neurology Medical College of Wisconsin Milwaukee Wisconsin USA

25. Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK

26. FutureNeuro Research Centre RCSI Dublin Ireland

27. Department of Computer Science and Engineering The Ohio State University Columbus Ohio USA

28. Cognitive Science Department Xiamen University Xiamen China

29. Fujian Key Laboratory of the Brain‐like Intelligent Systems Xiamen China

30. Instituto de Neurobiología Universidad Nacional Autónoma de México Querétaro Mexico

31. Division of Neurology Beaumont Hospital Dublin 9 Ireland

32. Department of Neurology Hôpital Erasme, Universite Libre de Bruxelles Brussels Belgium

33. Department of Neurology, Langone School of Medicine New York University New York NY USA

34. School of Medicine Trinity College Dublin Dublin Ireland

35. Functional Imaging Unit, Institute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald Greifswald Germany

36. Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research University of Tübingen Tübingen Germany

37. Department of Clinical Neurophysiology University Medicine Göttingen Göttingen Germany

38. The Welsh Epilepsy Unit, Department of Neurology University Hospital of Wales Cardiff UK

39. Institute of Neurology University “Magna Græcia” Catanzaro Italy

40. Cardiff University Brain Research Imaging Centre, School of Psychology Cardiff University Cardiff UK

41. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute University of Southern California Los Angeles California USA

42. The Florey Institute of Neuroscience and Mental Health Austin Campus Melbourne Victoria Australia

43. Florey Department of Neuroscience and Mental Health The University of Melbourne Melbourne Victoria Australia

44. Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK

45. Maryland Psychiatric Research Center, Department of Psychiatry University of Maryland School of Medicine Baltimore Maryland USA

46. Department of Neurology Zucker Hofstra School of Medicine New York New York USA

47. Department of Neuroscience, Central Clinical School Monash University Melbourne Victoria Australia

48. “Mario Serio” Department of Experimental and Clinical Biomedical Sciences University of Florence Florence Italy

49. Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia, NOCSE Hospital Modena Italy

50. Cleveland Clinic Neurological Institute Cleveland USA

51. The Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne Parkville Victoria Australia

52. Department of Neurology King's College Hospital London UK

53. Support Center for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital University of Bern Bern Switzerland

54. Medical Imaging Unit Central Finland Central Hospital Jyväskylä Finland

55. Neuroradiology Unit, Department of Head and Neck and Neurosciences Istituto Giannina Gaslini Genoa Italy

56. Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa Genoa Italy

57. Institute of Translational and Clinical Research Newcastle University Newcastle upon Tyne UK

58. Melbourne Brain Centre, Department of Medicine University of Melbourne Parkville Victoria Australia

59. Department of Neurology University Medicine Greifswald Greifswald Germany

60. Department of Neurology University of Ulm and Universitäts‐ and Rehabilitationskliniken Ulm Ulm Germany

61. Institute of Experimental Epileptology and Cognition Research University of Bonn Bonn Germany

62. Department of Computer Science and Electrical Engineering University of Maryland, Baltimore County Baltimore Maryland USA

63. Genomic Medicine Institute, Lerner Research Institute Cleveland Clinic Cleveland Ohio USA

64. Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge Massachusetts USA

65. Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK

66. Multimodal Imaging Laboratory University of California San Diego San Diego California USA

67. Department of Psychiatry University of California San Diego San Diego California USA

68. Chalfont Centre for Epilepsy Bucks UK

Funder

FP7 Ideas: European Research Council

Medical Research Council Canada

National Institutes of Health

Fondazione Antonio Carlo Monzino

Epilepsy Research UK

Katy Baggott Foundation

Publisher

Wiley

Subject

Physiology (medical),Neurology (clinical),Neurology,Histology,Pathology and Forensic Medicine

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